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Ro 8-4304 Hydrochloride

CAS No. 195988-65-9

Ro 8-4304 Hydrochloride( —— )

Catalog No. M21953 CAS No. 195988-65-9

Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM?Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ro 8-4304 Hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM?Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.
  • Description
    Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM?Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.?The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively.?Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    NMDA receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    195988-65-9
  • Formula Weight
    406.9
  • Molecular Formula
    C21H24ClFN2O3?
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NC(=O)c1ccc(OCC(O)CN2CCC(=CC2)c2ccc(F)cc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kew J N C , Trube G , Kemp J A . State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist[J]. British Journal of Pharmacology, 1998, 123(3):463-472.2. Huang S , Balgi A , Pan Y , et al. Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics[J]., 2016, 009(012):1620-1633.
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